Second-rows Iain Henderson and Tadhg Beirne have both been included in Ireland's squad to face Italy on Sunday, Irish Rugby has announced.
The pair had been included in original Six Nations squad but injuries forced both players to miss the opening rounds against England and Scotland.
Henderson could potentially miss the Italy game after being cited on his return from injury with Ulster.
He will face a disciplinary hearing today.
Leinster pair Garry Ringrose and Rhys Ruddock will miss the trip to Rome, with both players suffering from hamstring injuries.
They are set to remain with their province this week.
Ulster's Will Addison will also miss out with lower back stiffness and he is being managed by his province.
However, Munster's Chris Farrell was passed fit to train and has been included in the squad after being reviewed by the Ireland medical team.
The squad update comes on the back of the news that Robbie Henshaw has signed a new deal with the IRFU, keeping him at Leinster.
The Italians suffered bad injury news today, when it was announced that captain Sergio Parisse will miss Sunday's game after being injured playing for Stade Francais last weekend.
Ireland Squad to face Italy:
Rory Best (Banbridge/Ulster) 115 caps (c)
Tadhg Beirne (Lansdowne/Munster) 4 caps
Jack Conan (Old Belvedere/Leinster) 12 caps
Sean Cronin (St Mary’s College/Leinster) 67 caps
Ultan Dillane (Corinthians/Connacht) 12 caps
Tadhg Furlong (Clontarf/Leinster) 30 caps
Cian Healy (Clontarf/Leinster) 86 caps
Iain Henderson (Queens University/Ulster) 42 caps
Dave Kilcoyne (UL Bohemians/Munster) 26 caps
Jack McGrath (St Marys College/Leinster) 53 caps
Jordi Murphy (Lansdowne/Ulster) 26 caps
Sean O’Brien (UCD/Leinster) 54 caps
Peter O’Mahony (Cork Constitution/Munster) 54 caps (vc)
Quinn Roux (Galwegians/Connacht) 10 caps
James Ryan (UCD/Leinster) 15 caps
John Ryan (Cork Constitution/Munster) 16 caps
Niall Scannell (Dolphin/Munster) 11 caps
Josh van der Flier (UCD/Leinster) 15 caps
Bundee Aki (Galwegians/Connacht) 14 caps
Caolin Blade (Galwegians/Connacht) 0 caps
Adam Byrne (UCD/Leinster) 1 cap
Joey Carbery (Clontarf/Munster) 18 caps
Jack Carty (Buccaneers/Connacht) 0 caps
Andrew Conway (Garryowen/Munster) 10 caps
John Cooney (Terenure College/Ulster) 6 caps
Keith Earls (Young Munster/Munster) 74 caps
Chris Farrell (Young Munster/Munster) 4 caps
Tom Farrell (Coolmine/Connacht) 0 caps
Robbie Henshaw (Buccaneers/Leinster) 37 caps
Rob Kearney (UCD/Leinster/) 88 caps
Jordan Larmour (St Mary’s College/Leinster) 11 caps
Conor Murray (Garryowen/Munster) 69 caps
Jonathan Sexton (St Marys College/Leinster) 80 caps (vc)
Jacob Stockdale (Lurgan/Ulster) 16 caps