Joe McMahon has emerged as Tyrone's main injury concern ahead of their Ulster SFC quarter-final against Monaghan in Omagh on Sunday, June 5.
McMahon sustained a badly broken jaw and lost a number of teeth in an off-the-ball clash during a league game between his club Omagh St Enda's and Moortown last month.
Speaking at today's GAA Ulster Senior Football Championship launch, Tyrone manager Mickey Harte said: "Joe is the main concern and he is not going to be available so we have to accept that.
"We have known this from a while back, but other than that there are just a few niggles here and there. We are hopefully that will be able to deal with those niggles right enough."
Tyrone and Armagh have shared out all of the Ulster SFC titles on offer in the past 12 years, since Derry's triumph in 1998, but the Red Hands have struggled to impress so far this season.
Harte's charges did not have the best of league campaigns, but managed to hold onto their status as a Division 2 team.
Expectations are not high among Tyrone supporters at present, but the Tyrone manager says his side still have major goals.
"You like to be winning if you can and still contesting finals," he said.
"I wouldn't have chosen not to be in those places, but that is the way it was for us. History will tell us that we didn't make it out of Division 2 and didn't manage to get to the final so we have accept that.
"If we can add value to our game and learn from those league experiences then it will be OK.
"It's all about the Championship when it comes and you have to take it a round at a time. You have to stay in there as long as possible.
"Everybody is trying to do the same things and we are no different."