Mayo captain Andy Moran is likely to miss the All-Ireland semi-final against Dublin on September 2, after picking up a knee injury against Down yesterday.
Moran went off with a knee injury in the 55th minute of the Connacht champions' impressive 3-18 to 2-9 dismissal of Down at Croke Park.
Mayo GAA PRO Aiden McLoughlin confirmed that the Ballaghaderreen clubman is highly likely to be ruled out for the rest of the Championship.
A statement today from McLoughlin read: "Following a scan yesterday evening and a consultation this morning, it has been confirmed that Mayo captain Andy Moran has suffered significent ligament damage to his knee and will be getting further medical advice during the coming days.
"It is likely Andy Moran will miss the remainder of the season. Andy Moran has been a real leader on the team all year and will continue to do so.
"Andy Moran will still play a major role in the Mayo senior football team in their All-Ireland campaign this year. We wish Andy a speedy recovery and no doubt will see him back again soon."
Speaking in the aftermath of last night's game, Mayo manager James Horan said that it was disappointing to see the team captain forced to withdraw in the third quarter.
"Andy is the heartbeat and soul of the team, and he was playing great stuff so yes of course it's a disappointment," he said.
"But Andy will be the first to say that it's going to be an opportunity for someone else.
"When we get the diagnosis we'll take it from there, but there'll be an opportunity for someone else to slip in there and we're lucky that we have a strong panel and some good young players coming through - so we have to look at it that way.
"Of course it's disappointing for Andy. After the work he put in after a broken leg in the International Rules trials last year, he's done everything humanly possible to get back. He was in great shape so it's just very unfortunate from that point of view."
Reflecting on the overall team display, Horan was satisfied with his side's innings over the 70 minutes - however despite a comfortable victory the Mayo boss is still requesting more from his players.
"There were parts of the performance that were pleasing, and there were parts of it that weren't. We still didn't play like we can, but we showed flashes of it.
"We won the game and we've improved on the Connacht final, so we will be looking to do the same again for the next game. That's where it is."