Slovakia stunned world champions Germany with a 3-1 win in rain-soaked Augsburg on Sunday night.
Mario Gomez put Germany in front with a penalty, only for Marek Hamsik, Michal Duris and Juraj Kucka to turn the tide, the latter with the help of a terrible error by goalkeeper Marc-Andre ter Stegen.
Slovakia are now unbeaten in seven matches, with Northern Ireland awaiting in their final friendly before Euro 2016.
Nolito pressed his claims for inclusion in Spain's squad with two goals in a 3-1 victory over Bosnia-Herzegovina in Switzerland.
Emir Spahic hit back for Bosnia after Nolito's double, only to be sent off before half-time for clashing with Cesc Fabregas.
Chelsea forward Pedro claimed a late goal to seal Spain's win.
Southampton striker Graziano Pelle claimed the only goal as Italy saw off Scotland 1-0 in Malta.
Borussia Dortmund forward Henrikh Mkhitaryan's hat-trick spearheaded Armenia's 7-1 rout of Guatemala.
The 27-year-old led the way as Armenia recovered in style from slipping 1-0 behind to Carlos Ruiz's seventh-minute goal.
Edgar Manucharyan, Gegham Kadimyan, Arthur Sarkisov and Zaven Badoyan all found the net as Armenia romped home.
Ukraine brushed Romania aside 4-3, scoring all their goals inside the hour before easing off the gas to coast home.
Gabriel Torje gave Romania the 23rd-minute lead before Roman Zozulya, Aleksandr Zinchenko, Yevhen Konoplyanka and Andriy Yarmolenko turned the tide well and truly in Ukraine's favour.
Denis Alibec and Nicolae Stanciu netted late on for the hosts, but by that stage Ukraine had already relaxed into their win.
Mehmet Topal pilfered Turkey a 1-0 victory over Montenegro by firing the game's solitary goal in the fourth minute of added time.
Nerijus Valskis and Fiodor Cernych supplied the goals as Lithuania overwhelmed Estonia 2-0, while Albania swept past Qatar 3-1.
Arlind Ajeti, Ermir Lenjani and Armando Sadiku put Albania in cruise control, after Abdelkarim Hassam's early strike for Qatar.
The United States thumped Bolivia 4-0, Gyasi Zardes bagging a brace and John Brooks and Christian Pulisic also finding the net.
Raul Ruidiaz, Andy Polo and Yoshimar Yotun were all on target in Peru's 3-1 victory over El Salvador, who had Nelson Bonilla to thank for their solitary strike.