Germany's Philipp Kohlschreiber was the first seed to fall in the men's draw at Wimbledon on the opening day.
The 32-year-old, competing in his 12th straight Wimbledon, fell in four sets to Frenchman Pierre-Hugues Herbert, the US Open doubles champion.
A 7-5 6-3 3-6 6-3 defeat for Kohlschreiber not only means an early exit but also that he has gone home in the first round of all three grand slams in 2016.
The Wimbledon 21st seed lost to Nicolas Almagro in France last month and to Kei Nishikori in Australia at the start of the year.
The ninth seed, Marin Cilic, had no such struggles as he beat America's Brian Baker in straight sets, while Sergiy Stakhovsky was a three-set victor over Japan's Yoshihito Nishioka.