Dundalk have been drawn in a group containing Zenit Saint Petersburg of Russia , A.Z. Alkmaar of the Netherlands and Maccabi Tel-Avi of Israel in the Europa league.
Manchester United face a trip into the unknown after being drawn against Ukrainian side Zorya Luhansk in the Europa League.
The European debutants - who reached the play-offs in the last two years but failed to progress - are based in the east of the country close to the border with Russia.
However, because of the war in that part of the country Jose Mourinho's side are set to play at the Slavutych Arena in Zaporizhia, which is more centrally located.
United's other two opponents are far more familiar in Fenerbahce and Feyenoord.
Southampton have a glamour tie against Inter Milan and have also been drawn against Sparta Prague and Israel's Hapoel Be'er Sheva, who gave Celtic a scare in their Champions League qualifier.
The campaign begins on September 15th.