Diafra Sakho is out of West Ham's return to Old Trafford in the EFL Cup quarter-final.
The striker scored the opening goal in Sunday's 1-1 Premier League draw away against Manchester United, but then suffered a hamstring injury.
Andy Carroll is close to returning from a knee problem but will probably be saved for Saturday's visit of Arsenal. Defender Winston Reid is available after suspension.
Provisional squad: Adrian, Randolph, Collins, Ogbonna, Reid, Cresswell, Kouyate, Noble, Obiang, Fernandes, Nordtveit, Payet, Lanzini, Antonio, Feghouli, Ayew, Sakho, Zaza, Fletcher.