There's a first cap for winger Megan Williams in the Ireland women's side for their first Six Nations game against France on Saturday.
With options scarce at out-half, Niamh Briggs has been handed the number 10 jersey.
Connacht's Laura Feely should make her debut off the bench.
Ireland face the French in Toulouse on Saturday evening, and despite the many changes in the squad, captain Ciara Griffin insists, "we still want to win every game in a green jersey".
Speaking ahead of the clash, head coach Adam Griggs said, "The opening game of this tournament is always going to be a challenge and France in front of their home crowd is immense.
"However, the squad have had good preparation over the last 2 weeks and are excited and focused on the challenge at hand to start our campaign off with a positive performance.”
Ireland Women's Team:
15 - Kim Flood (Railway Union/ Leinster)
14 - Megan Williams (Old Belvedere/ Leinster) *
13 - Claire McLaughlin (Cooke/ Ulster)
12 - Sene Naoupu (Railway Union/ Leinster)
11 - Alison Miller (Portloaise /Connacht)
10 - Niamh Briggs (UL Bohemian / Munster)
9 - Ailsa Hughes (Railway Union/ Leinster)
1 - Lindsay Peat (Railway Union/ Leinster)
2 - Cliodhna Moloney (Railway Union/ Leinster)
3 - Fiona Reidy (UL Bohemian/ Munster)
4- Ciara Cooney (Railway Union/ Leinster)
5 - Orla Fitzsimons (St Mary's/ Leinster)
6 - Anna Caplice (UL Bohemians/ Munster)
7 - Claire Molloy (Bristol / Connacht)
8 - Ciara Griffin (Tralee/ Munster) Captain
16 - Leah Lyons (Highfield/ Munster)
17 - Laura Feely (Galweigians/ Connacht) *
18 - Ciara O'Connor (Galwegians/ Connacht)
19 - Nichola Fryday (Tullamore/ Connacht)
20 - Paula Fitzpatrick (St Mary's/ Leinster)
21 - Mary Healy (Galwegians/ Connacht)
22 - Nikki Caughey (Railway Union/ Ulster)
23 - Mairead Coyne (Galwegians / Connacht)