David Moyes has named Robin van Persie, Wayne Rooney and Juan Mata together in his Manchester United starting line-up for the first time as the Red Devils look to maintain their Barclays Premier League momentum at Stoke.
Rooney’s return is one of three changes for the visitors, who also have Michael Carrick and Tom Cleverley back in the centre of midfield.
Peter Odemwingie is handed his home debut by Mark Hughes, whose Stoke side have collected just one point from their last six games.
Stoke: Begovic, Cameron, Shawcross, Wilson, Pieters, Adam, Whelan, Odemwingie, Arnautovic, Walters, Crouch.
Subs: Muniesa, Palacios, Guidetti, Assaidi, Sorensen, Shotton, Ireland.
Man Utd: De Gea, Jones, Smalling, Evans, Evra, Cleverley, Carrick, Young, Rooney, Mata, van Persie.
Subs: Da Silva, Lindegaard, Hernandez, Welbeck, Fletcher, Valencia, Januzaj.
Referee: Neil Swarbrick (Lancashire)
Fulham v Southampton
Lewis Holtby and William Kvist have been handed their Fulham debuts in the Barclays Premier League meeting with Southampton.
The new signings are part of four changes made by Rene Meulensteen, who also brings Darren Bent and Damien Duff into his team at Craven Cottage.
Southampton make two alterations, with Victor Wanyama and Rickie Lambert returning from injury in place of Jack Cork and Sam Gallagher.
Fulham: Stekelenburg, Riether, Hangeland, Burn, Richardson, Sidwell, Parker, Kvist Jorgensen, Holtby, Bent, Duff.
Subs: Kasami, Kacaniklic, Stockdale, Rodallega, Dempsey, Tankovic, Passley.
Southampton: Boruc, Chambers, Fonte, Yoshida, Shaw, Schneiderlin, Wanyama, Lallana, Steven Davis, Rodriguez, Lambert.
Subs: Kelvin Davis, Clyne, Ward-Prowse, Cork, Do Prado, Hooiveld, Gallagher.
Referee: Mike Jones (Cheshire)
Everton v Aston Villa
Winger Aiden McGeady makes his first ever Barclays Premier League start as Everton look to bounce back from their Merseyside derby thrashing when they take on Aston Villa at Goodison Park.
Defender Sylvain Distin return more quickly than expected from a hamstring problem while Leon Osman also starts, with Kevin Mirallas to play up front in the absence of Romelu Lukaku and Lacina Traore.
Striker Grant Holt makes his first start for Villa in one of two changes from the 4-3 derby victory over West Brom on Wednesday. Nathan Baker also comes in.
Everton: Howard, Stones, Jagielka, Distin, Baines, McCarthy, Barry, McGeady, Osman, Barkley, Mirallas.
Subs: Robles, Hibbert, Naismith, Pienaar, Coleman, Vellios, Garbutt.
Aston Villa: Guzan, Bacuna, Baker, Vlaar, Clark, Bertrand, Weimann, Delph, Westwood, Holt, Benteke.
Subs: El Ahmadi, Helenius, Albrighton, Steer, Sylla, Tonev, Lowton.
Referee: Robert Madley (West Yorkshire)
Hull v Spurs
Tottenham welcome Jan Vertonghen and Paulinho back for their Barclays Premier League visit to Hull.
Vertonghen has not played since injuring his ankle on December 4 but is back for his first appearance under Tim Sherwood, while Paulinho replaces Mousa Dembele in central midfield.
Hull, without a point or a goal in their last four games, have goalkeeper Steve Harper in for the suspended Allan McGregor, while there are home debuts for £14million strike duo Nikica Jelavic and Shane Long.
Hull: Harper, Elmohamady, Davies, McShane, Figueroa, Rosenior, Meyler, Huddlestone, Brady, Jelavic, Long.
Subs: Bruce, Koren, Fryatt, Jakupovic, Boyd, Sagbo, Quinn.
Spurs: Lloris, Walker, Dawson, Vertonghen, Rose, Lennon, Bentaleb, Paulinho, Eriksen, Adebayor, Soldado.
Subs: Kaboul, Capoue, Naughton, Chadli, Sigurdsson, Friedel, Kane.
Referee: Anthony Taylor (Cheshire)
Cardiff v Norwich
Fabio and Kenwyne Jones are handed their Cardiff debuts in the Barclays Premier League meeting with Norwich.
The full-back and striker are preferred to Kevin Theophile-Catherine and Fraizer Campbell respectively, but Wilfried Zaha has to settle for a place on the bench following his loan move from Manchester United.
Norwich boss Chris Hughton brings in Alexander Tettey, Jonas Gutierrez and Johan Elmander for Leroy Fer, Anthony Pilkington and Ricky van Wolfswinkel, but there is no place for Wes Hoolahan.
Cardiff: Marshall, John, Turner, Caulker, Da Silva, Noone, Mutch, Medel, Whittingham, Bellamy, Jones.
Subs: Campbell, Eikrem, Gunnarsson, Theophile-Catherine, Daehli, Lewis, Zaha.
Norwich: Ruddy, Martin, Bassong, Ryan Bennett, Olsson, Snodgrass, Johnson, Tettey, Gutierrez, Elmander, Hooper.
Subs: Whittaker, van Wolfswinkel, Fer, Pilkington, Bunn, Becchio, Redmond.
Referee: Mark Clattenburg (Tyne & Wear)