Liverpool boss Rafael Benitez recalled Fabio Aurelio at left-back in place of Andrea Dossena for this Champions League group D clash – the only change from the side that won the Merseyside derby at Everton on Saturday.
It meant that for the manager’s 250th game in control at Anfield, Javier Mascherano was left on the bench despite recovering from a calf injury.
PSV made three changes from the side that beat Eredivisie bottom club Volendam at the weekend, with striker Danny Koevermans sacrificed for extra defensive strength.
Nordin Amrabat, Jason Culina and Otman Bakkal came into a side that included former Liverpool defender Jan Kromkamp.
Liverpool: Reina, Arbeloa, Skrtel, Carragher, Aurelio, Kuyt, Gerrard, Alonso, Riera, Torres, Keane. Subs: Cavalieri, Dossena, Agger, Benayoun, Babel, Mascherano, Leiva Lucas.
PSV: Isaksson, Kromkamp, Simons, Marcellis, Salcido, Brechet, Mendez, Culina, Bakkal, Amrabat, Wuytens. Subs: Cassio, Rodriguez, Zonneveld, Koevermans, Pieters, Nijland, Dzsudzsak.
Referee: Felix Brych (Germany)