The first flight to collect more Personal Protective Equipment for frontline staff is due to take off this morning.
The Aer Lingus cargo plane will have a 50-hour round trip to China to bring the consignment back, and is due to arrive tomorrow evening.
The HSE is spending more than €230m to buy the much-needed supplies for healthcare staff in the battle against the coronavirus.
Chief operations officer with the HSE, Anne O'Connor, said it is to ensure enough PPE for all services in the weeks and months ahead.
Ms O'Connor said: "We have already, since the first of February, brought in €30m worth of PPE, there is another €30m starting to arrive on Sunday.
"The best part of that will see 10 flights between Sunday and Wednesday coming into Ireland so the shipment overall will see 300 flights coming in.
"So it is a very, very significant supply chain that we have secured and we would see that we would have PPE over the coming weeks and months throughout all services."