The Tánaiste says assisted suicide should be legislated for - putting him in direct conflict with the Taoiseach on the issue.
Eamon Gilmore made the comment in the Dáil responding to Independent TD Stephen Donnelly.
His comments come after Wicklow woman Marie Fleming lost a Supreme Court case on the ban on assisted suicide earlier this year.
The Tánaiste says while the Dáil should do as the Supreme Court says and legislate, it won't be easy.
"I think it's a difficult issue. I have enormous sympathy for the situation [Marie Fleming] finds [herself] in – but there is not simple answer," he said.
"When we come to look at this issue in terms of legislation, this isn't' going to be a simple, straightforward issue."