Planning permission is expected to be lodged later for the new National Children's Hospital at St James's in Dublin.
The €650m development would combine the services at the three existing hospitals in Crumlin, Tallaght and Temple Street.
However, children's groups have objected to the location of the new hospital, with some saying it should be built on the campus of Connolly Hospital in Blanchardstown.
The planning application being lodged today includes a hospital, parent accomodation and research buildings at the St James's campus.
It also features plans for two out-patient and urgent care centres at Blanchardstown and Tallaght hospitals.
The location for the National Children's hospital was chosen in November 2012 after An Bord Pleanala rejected an earlier application placing it at the Mater Hospital.
There has been opposition to the plans from children's groups who say the location is wrong.
CEO of the Jack and Jill foundation, Jonathan Irwin, says that there are a lot of problems with the current plan.
He said: "It's in the wrong place, the access is very poor, it's a very congested part of Dublin and parking is woeful.
"Security problems around the area, along the campus of St James', are very high risk.
"The building itself is very good, it's the location that's a disaster and far too costly."