Taoiseach Enda Kenny will holds talks with British Prime Minister Theresa May today in the latest meetings on how Brexit will unfold.
Mr Kenny, who last week met French president Francois Hollande on the issue, said his trip to London offers a chance for constructive discussions.
"I look forward to meeting with Prime Minister May," the Taoiseach said.
"This meeting will provide an opportunity for us to have a strategic and constructive discussion on the impact of the referendum and how we are going to work together to protect the interests of all our citizens on these islands."
The two leaders will hold talks in Downing Street at lunchtime.
The meeting takes place a day after Mrs May met the Northern Ireland First and Deputy First Ministers Arlene Foster and Martin McGuinness in Belfast.
The Irish Government said the meeting would allow Mrs May and Mr Kenny to exchange views on a wide range of issues of mutual interest including the situation in the North.