The Government has passed legislation for the first time allowing for abortion in limited circumstances.
The vote passed with a comfortable majority, with 127 voting in favour and 31 against.
Despite fears some backbenchers would revolt, Minister for European Affairs Lucinda Creighton was one of only five to break Government ranks.
She has now given her letter of resignation to the Taoiseach.
The Protection of Life During Pregnancy Bill legalises termination of a pregnancy if a woman’s life is at risk, including from the threat of suicide.