Update June 29, 12.30pm:Karen Scott has been found safe and well.
Update 7.32pm: Gardai in Finglas have issued a further update on the last confirmed sighting of missing woman Karen Scott.
The 44 year old, who has Down Syndrome, has not previously travelled outside Dublin city, as far as gardaí are aware.
This latest sighting was at a licensed premises located on Burgh Quay, Dublin 2 last Friday, June 24.
She was seen on CCTV leaving the premises at approximately 9.40pm, she turned left on exiting the premises and can be seen turn left onto D'Olier St.
She was wearing the same clothes as originally reported (white runners, peach coloured hoody and black jeans ) and she was in possession of her red suitcase.
Gardaí have said they are increasingly concerned about missing Dublin woman Karen Scott, who has Down Syndrome.
Forty-four-year-old Karen Scott from Finglas left her home on Friday afternoon with a red suitcase.
Gardaí have said they have one confirmed sighting of Karen - she was spotted on Berkeley Road in Phibsboro that evening.
There have been other reported sightings, including at Penneys in Patrick Street in Cork, and garda are following this up, as well as other reported sightings. These sightings have not been confirmed at this stage.
Karen has not previously travelled outside Dublin city, as far as gardaí are aware.
Inspector John Burke said the fact that Karen has special needs is adding to their concerns: "She is described as approximately 5ft 4in tall, medium build, blue eyes and short blond hair.
"Last seen she was wearing white runners, peach coloured hoody and black jeans. Obviously her family are very, very concerned about her as is the community in Finglas.
"We have had a reasonably good response to all the appeals that have gone out over the weekend. We are following a good few lines of inquiry…We are anxious to locate her."
Karen had a number of brightly coloured tops with her in reds, greens and blues. She may have had some money with her, but as far as gardaí know she had no passport with her. She had no mobile phone with her.
She has not previously left home for this length of time. Nobody has reported speaking to Karen since she went missing.
Anyone with information is asked to contact Finglas garda station on 01 6667500.