Four hundred new jobs are to be created at a brand new bio technology plant near Dunboyne in Co Meath.
The highly skilled, full time positions at Shire will be in the areas of R&D, operations and technical staff.
Shire - who develop medicines to treat rare diseases - already have a small operation at City West in Dublin.
The Minister for Jobs Richard Bruton said 700 people would also be employed during the construction of the new facility at Piercetown.
The company hope to open the new plant by 2019.