An adaptation of Chris Adrian and Eli Horowitz's novel, The New World, will be Sharon Horgan first foray into directing feature films.
The 48-year-old star is the creative force behind a number of programmes, including Catastrophe, Motherland, and HBO’s Divorce.
The New World centres on the recently widowed Jane, whose late husband Jim had his head cryogenically frozen by a shadowy company.
Jim, it transpires, is awake in "an afterlife of sorts" - and Jane sets out to find his head.
Focus Features has secured the rights to develop the film and Alicia Van Couvering and Olivia Wilde will produce.