The 32-year-old actor, who starred as the iconic comic book character in two films, in 2012 and 2014, before he was recently replaced by Tom Holland, has revealed his hope of seeing a more diverse superhero world in the coming years.
Asked about the contractual obligations of the character, he said: "I'm excited to get to the point where we don't have to have this conversation, where we can have a pan-sexual Spider-Man."
Andrew suggested Hollywood was fearful of having an iconic character being portrayed in a way that deviates from earlier incarnations.
He told Mic: "The richness of the world we're in, the diversity of the world we're in; you look at the animal kingdom and you see it reflected. You look all over.
"What are we so scared of? Why are we so, 'No, it has to be this way, a man and a woman.' Why is that even a conversation?"
Back in 2013, Andrew voiced his support for a gay version of Spider-Man.
He said: "Why can't we discover that Peter is exploring his sexuality? It's hardly even groundbreaking!
"Why can't he be gay? Why can't he be into boys?"