ISME has decided to support the ratification of the Lisbon Treaty.
The decision was taken after consideration of the guarantees from the EU Heads of State secured by the Government.
At a recent meeting of the National Council of the Irish Small & Medium Enterprises Association, Eilis Quinlan said: "It is now more important than ever that Ireland remains a pivotal constituent of the European project.
"Our support of the Lisbon Treaty will allow us retain our role in Europe and assist in developing our business relationships within and outside the Union, which will not only benefit indigenous small and medium business, but the whole of Irish Society.
"Europe has provided significant opportunities for Irish SMEs in the past and will continue to do so. The challenges of the 21st century will be of such a scale that no one country, no matter how big, will be able to face alone. Over the years since 1973, Ireland has played an important role in developing the EU. We now must be brave enough as a nation to persistently pursue Ireland’s interests and the interests of Small & Medium Enterprises within the European Union.
"It is hugely important, not only for this generation but for the generations to come, that the Irish people, including those in the business community, safeguard the hard earned positive reputation that we have developed within the Union," she concluded