The former Apollo House site has gone up for sale.
The building, which has since been demolished, was the location for one of Dublin's first housing occupations in 2016.
Planning permission has already been granted for a 10-storey office block, retail unit, cafe, bar and restaurants.
The site, which saw 'Home Sweet Home' activists occupy the building for over a month from December 2016, has been placed on the market for sale on the instruction of Simon Coyle and Tom O'Brien of Mazars - who have appointed Savills to handle the sale.
Industry sources believe it could be sold for up to €40m.
The 0.72 acre has planning permission for a 10-storey, over basement 12,622 sq m (135,863 sq ft) office block.
The planning permission also allows for ground floor retail, café, bar and restaurant units.
Designed by architects Henry J Lyons, the new building will feature a double basement providing 40 car parking spaces and 166 bicycle spaces.
A wrap-around terrace on the eight-floor will give panoramic views of the Dublin Docklands, with additional outdoor space available on most of the upper levels.
The Apollo House itself has already been demolished.
Mark Reynolds is director of development and consultancy at Savills Ireland.
He said: "There are very few sites with development potential remaining in Dublin's CBD (Central Business District), so this truly is one of the last opportunities to acquire a site of scale in a location where demand for office space is strong.
"We expect there to be interest from a variety of buyers, including developers, REITs, pension funds and investors."
In the last two years, office-based employment in Dublin has risen by 8.2%, with an additional 18,800 office-based jobs created in that time.
As a result, Savills says, demand for office space is at its highest level.