‘Nanoparticles’ may help scientists develop MS jab
Monday, November 19, 2012
By John von Radowitz
Tiny synthetic particles could help scientists to develop vaccines against immune response diseases such as multiple sclerosis (MS), research has shown.
The “nanoparticles” trick the immune system into calming down and behaving normally.
In tests on mice, they halted a rodent version of relapsing-remitting MS, the most common form of the autoimmune disease.
Scientists believe the technology could be applied to a range of immune system disorders, including type-1 diabetes, food allergies, and asthma.
MS occurs when the immune system attacks myelin, the fatty insulation that surrounds nerve fibres. Breaks in the myelin coating prevent nerve messages being transmitted properly, leading to symptoms ranging from numbness and tingling to full-blown paralysis.
Current treatments for MS rely on suppressing the immune system, which can make patients susceptible to infections and cancer.
Instead, the nanoparticle vaccine re-sets the immune system to stop the “friendly fire” attacks.
The nanoparticles, made from two biodegradable compounds that naturally occur in the body, are attached to myelin proteins.
Injected into sick mice, the nanoparticles were viewed by the immune system as ordinary dying blood cells which can be ignored. This also caused the immune system to tolerate the myelin proteins attached to them.
Having learned to accept the proteins, the immune system also stopped attacking myelin- wrapped nerve fibres.
Study leader Professor Stephen Miller, from Northwestern University in Chicago explained: “We administered these particles to animals who have a disease very similar to relapsing-remitting MS and stopped it in its tracks. We prevented any future relapses for up to 100 days, which is the equivalent of several years in the life of an MS patient.”
The research is reported in the journal Nature Biotechnology.
Prof Miller’s team is now adapting the nanoparticles to treat type-1 diabetes, and asthma.
He said: “This is a highly significant breakthrough in translational immuno- therapy.
“The beauty of this new technology is it can be used in many immune-related diseases. We simply change the antigen [the protein] that’s delivered.”
The aim was to provide a targeted treatment, unlike immunosuppression which weakens the whole immune system, said the researchers.
The nanoparticles are made from a long-chain molecule called PLG consisting of lactic acid and glycolic acid.
Both compounds are natural break-down products of metabolism in the human body.
PLG is already approved for medical treatments and is commonly used for biodegradable wound sutures.
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