Don't freak out, but scientists think octopuses 'might be aliens' after DNA study

Not to send you into a meltdown or anything but octopuses are basically ‘aliens’ – according to scientists.


Researchers have found a new map of the octopus genetic code that is so strange that it could be actually be an “alien”.

The first whole cephalopod genome sequence shows a striking level of complexity with 33,000 protein-coding genes identified – more than in a human.

California two-spot octopus
(Yen-Chui Liu)

Not only that, the octopus DNA is highly rearranged – like cards shuffled and reshuffled in a pack – containing numerous so-called “jumping genes” that can leap around the genome.

“The octopus appears to be utterly different from all other animals, even other molluscs, with its eight prehensile arms, its large brain and its clever problem-solving abilities,” said US researcher Dr Clifton Ragsdale, from the University of Chicago.

California two-spot octopus
(Yen-Chui Liu)

“The late British zoologist Martin Wells said the octopus is an alien. In this sense, then, our paper describes the first sequenced genome from an alien.”

The scientists sequenced the genome of the California two-spot octopus in a study published in the journal Nature.

Octopus bimaculoides
(Yen-Chui Liu)

They discovered unique genetic traits that are likely to have played a key role in the evolution of characteristics such as the complex nervous system and adaptive camouflage.

Analysis of 12 different tissues revealed hundreds of octopus-specific genes found in no other animal, many of them highly active in structures such as the brain, skin and suckers.

California two-spot octopus
(Yen-Chui Liu)

The scientists estimate that the two-spot octopus genome contains 2.7 billion base pairs – the chemical units of DNA – with long stretches of repeated sequences.

And although the genome is slightly smaller than a human’s, it is packed with more genes.

California two-spot octopus
(Yen-Chui Liu)

Reshuffling was a key characteristic of the creature’s genetic make-up. In most species, cohorts of certain genes tend to be close together on the double-helix DNA molecule.

A gene is a region of DNA that contains the coded instructions for making a protein.

A juvenile California two-spot octopus.
(Yen-Chui Liu)

In the octopus, however, there are no such groupings of genes with related functions. For instance, Hox genes – which control body plan development – cluster together in almost all animals but are scattered throughout the octopus genome.

It was as if the octopus genome had been “put into a blender and mixed”, said co-author Caroline Albertin, also from the University of Chicago.

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